STEM CELL BIOLOGIST (CILIOPATHY RESEARCH)

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General Information

Position available in the laboratory of Dr. Holly Chen at the University of Alabama at Birmingham for stem cell biologists to facilitate the establishment of a new laboratory focusing on modeling ciliopathies in vitro using stem cell-based platforms. The primary cilium is a key microtubule-based organelle that senses external environment and modulates diverse signaling pathways in multiple tissues and cells. Aberrant cilium biogenesis and/or ciliary transport and functions lead to numerous diseases collectively termed ciliopathies. Clinical manifestations of ciliopathies range of sensory defects to syndromic disorders with multi-organ pathologies. However, the underlying molecular mechanisms of diseases pathologies are poorly understood, and the genotype-phenotype correlations remain unclear. In addition, animal models do not completely recapitulate the pathophysiology of ciliopathies in humans, posing further challenges for developing treatments. The long-term goals of my research are to understand molecular mechanism(s) of cilium biogenesis and ciliopathies and develop treatment modalities using complementary strategies of mouse models and patient induced pluripotent stem cell (iPSC)-based culture systems coupled with a broad array of approaches from molecular biology to transcriptomics, proteomics and genomics.

General Responsibilities

Under minimal supervision, to lead and perform a range of stem cell-based experiments. To work collaboratively with other lab members and collaborators.

Key Duties & Responsibilities

1. Independently perform lab-based experiments including reprogramming of human somatic cells into induced pluripotent stem cells, banking and validating stem cells, differentiating induced pluripotent stem cells into organoids, identifying disease-associated phenotypes using cellular, molecular and functional assays.
2. Work efficiently and cooperatively with researchers within the lab to proactively support all aspects of the labrsquo;s research.
3. Work with lab members and the PI to prepare reports and manuscripts.

Salary

Salary commensurate with experience.

Requirements

Applicants must have a bachelorrsquo;s degree in Biology, Biochemistry, or a closely related field upon starting the position. At least 1-year intensive cell culture experience and flexibility on working schedules including weekends are required.

Preferences

Previous experiences with stem cells or proteomics are highly preferred.

Key Skills

• Commitment to teamwork with a diverse group of people
• Effective verbal and written communication skills
• Highly self-motivated
• Strong organizational skills and attention to detail.
• Basic Knowledge of laboratory equipment, techniques, computer skills, and safety regulations
• Ability to deal with challenging, time-sensitive tasks and situations

Lab Information

Holly Chen

Assistant Professor

Department of Cellular, Developmental and Integrated Biology (CDIB)